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KMID : 0613820080180050653
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Journal of Life Science
2008 Volume.18 No. 5 p.653 ~ p.659
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Inhibitory Effect of Mulberry Extracts on Angiogenesis in Porcine Pulmonary Artery Endothelial Cells
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Lee Suk-Hee
Kim Hwan-Gyu
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Abstract
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Endothelial cells release proteinases to degrade the extracellular matrix for their migration and sprouting in vivo. In the present study, we investigated the inhibitory effect of mulberry extracts on the migration and sprouting activity of porcine pulmonary artery endothelial cells (PPAECs). Mulberry extracts significantly inhibited migration and sprouting of PPAECs. Mulberry extracts inhibited expressions and secretions of matrix metalloproteinase-2 (MMP-2) and MMP-9. Our results suggest that the inhibitory effects of mulberry extracts on migration and sprouting of PPAECs are, in part, associated with the decreased secretion of MMP-2 and MMP-9.
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KEYWORD
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Mulberry extracts, angiogenesis, matrix metalloproteinases (MMPs), migration
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